Generic Sovaldi (Sofosbuvir) Available for Online Order – Indications, Effects, Contraindications, Price

Understanding Generic Sovaldi (Sofosbuvir)

Overview of Generic Sovaldi

Generic Sovaldi, also known by its generic name sofosbuvir, is a medication used in the treatment of chronic hepatitis C virus (HCV) infection. It belongs to a class of drugs called direct-acting antivirals (DAAs) and has revolutionized the management of hepatitis C.

Sovaldi was initially developed by Gilead Sciences and received approval from the United States Food and Drug Administration (FDA) in 2013. It was hailed as a breakthrough in the field of hepatitis C treatment due to its high efficacy and relatively few side effects. However, the high cost of the branded medication posed challenges to its widespread accessibility.

In recent years, generic versions of Sovaldi have become available, offering a more affordable alternative to the branded drug. Generic drugs are bioequivalent to their branded counterparts, meaning they contain the same active ingredient and have the same strength, dosage form, and route of administration. This drug contains sofosbuvir as its active ingredient and works in the same way as the branded version.

Sofosbuvir, the active component of Sovaldi, acts by targeting a specific enzyme in the hepatitis C virus, inhibiting its replication and reducing viral load. It is effective against multiple genotypes of the hepatitis C virus, making it a versatile treatment option.


Generic Sovaldi (Sofosbuvir) is used to treat a range of diseases caused by the hepatitis C virus (HCV). It is indicated for the management of chronic hepatitis C infection, providing a potent and effective therapy option. This medication is particularly beneficial for individuals diagnosed with hepatitis C, regardless of the specific genotype of the virus they have. It has shown efficacy in treating various genotypes of HCV, making it a versatile treatment choice. By inhibiting viral replication, Sovaldi helps to reduce the viral load in patients and improve their overall liver health. Its availability has significantly expanded access to affordable treatment for hepatitis C, addressing barriers that were previously associated with the cost of branded medications.

Administration and Dosage

Recommended dosage

The recommended prescribed dosage of Generic Sovaldi (Sofosbuvir) can vary depending on factors such as the specific hepatitis C genotype, the presence of co-existing liver conditions, and the treatment regimen being followed. It is essential to consult a healthcare professional for personalized dosing instructions. However, here is a general guideline:

For most hepatitis C patients, the standard recommended dosage of Generic Sovaldi is 400 mg (one tablet) taken orally once a day. It is often used in combination with other antiviral medications, such as ribavirin or other direct-acting antivirals, as part of a comprehensive treatment regimen. The duration of treatment can also vary based on individual factors, including the hepatitis C genotype and the patient’s treatment response.

It’s crucial to follow the prescribed dosage instructions provided by the healthcare professional, as they will tailor the treatment plan to each patient’s specific needs. Any adjustments to the dosage or treatment duration should only be made under the guidance of a healthcare professional.

Administration instructions

When taking this generic analog, it is important to carefully follow the administration instructions provided by your healthcare professional. Here are some essential guidelines:

  1. Oral Administration: It is taken orally, which means it is ingested by mouth. Swallow the tablet whole with water, without crushing, breaking, or chewing it.
  2. Timing: Take the prescribed dosage at approximately the same time each day to maintain a consistent level of the medication in your system.
  3. Combination Therapy: Sovaldi is often used in combination with other antiviral medications. Follow your healthcare professional’s instructions regarding the timing and administration of these medications, as they may have specific requirements.
  4. Food Interactions: It can be taken with or without food. However, it is advisable to check with your healthcare professional if there are any specific dietary considerations or restrictions while taking this medication.
  5. Missed Dose: If you accidentally miss a dose of Sovaldi, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
  6. Duration of Treatment: The duration of treatment can vary depending on individual factors and the specific hepatitis C genotype. Follow your healthcare professional’s instructions regarding the duration of treatment and complete the full course as prescribed, even if you start feeling better.
  7. Consultation: Throughout your treatment, maintain regular communication with your healthcare professional. Inform them about any changes in your health or any side effects you may experience.

Missed dose

If you happen to miss a dose of Generic Sovaldi (Sofosbuvir), it is recommended to take it as soon as you remember. However, if it is already close to the time for your next scheduled dose, it is advisable to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

It’s important to note that missing a single dose is unlikely to significantly affect the overall efficacy of your treatment. However, it’s always best to consult your healthcare professional for personalized advice in such situations. They can provide specific guidance based on your individual circumstances and help ensure that you maintain an optimal treatment schedule.

Precautions and Safety Measures


Generic Sovaldi (Sofosbuvir) has certain contraindications, meaning there are specific conditions or situations in which its use is not recommended. It is important to consult with a healthcare professional to determine if Sovaldi is suitable for you. Here are some common contraindications:

  1. Hypersensitivity: Individuals who have had a previous hypersensitivity or allergic reaction to sofosbuvir or any of the components in the medication should not take Sovaldi.
  2. Pregnancy: Sovaldi is not recommended for use during pregnancy. It is essential to discuss pregnancy plans with your healthcare professional before starting treatment, as the potential risks to the fetus need to be carefully considered.
  3. Breastfeeding: It is not known whether it passes into breast milk. Therefore, breastfeeding individuals should consult with their healthcare professional to assess the potential risks and benefits before using this medication.
  4. Concurrent Use with Certain Medications: It can interact with other medications, including those metabolized by the enzyme CYP2B6 or CYP2C8. It is important to inform your healthcare professional about all the medications, supplements, and herbal products you are taking to avoid potential drug interactions.
  5. Severe Liver Dysfunction: Sovaldi should be used with caution in individuals with severe liver dysfunction, as there may be a need for dose adjustments or additional monitoring.

Drug interactions

Common drug interactions of Sovaldi (Sofosbuvir) can occur when it is used in combination with other medications. Here are some notable drug interactions associated with the therapy:

  1. Amiodarone: Co-administration of Sovaldi with amiodarone, a medication used to treat irregular heart rhythms, can increase the risk of serious and potentially life-threatening bradyarrhythmias (slow heart rate). Close monitoring of heart function is advised when these medications are used together, and alternative treatment options may be considered.
  2. Rifampin and St. John’s Wort: Rifampin, an antibiotic, and St. John’s Wort, a herbal supplement, can significantly decrease the concentration of Sofosbuvir in the body, potentially reducing its effectiveness. Avoiding the concomitant use of Sovaldi with these substances is generally recommended.
  3. Certain HIV Medications: Sovaldi is sometimes used in combination with certain antiretroviral medications for the treatment of individuals co-infected with HIV and HCV. However, some antiretroviral drugs, such as efavirenz and tipranavir/ritonavir, can reduce the concentration of Sofosbuvir in the blood. Close monitoring and potential dosage adjustments may be necessary when using Sovaldi with these HIV medications.
  4. Acid-Reducing Agents: Medications that reduce stomach acid, such as proton pump inhibitors (PPIs) and H2 blockers, can decrease the absorption of Sovaldi. It is generally recommended to avoid taking this medicationsimultaneously with these acid-reducing agents. If needed, a time interval between the administration of Sovaldi and these medications may be recommended.

Special populations

When it comes to the intake of Sovaldi (Sofosbuvir) in special populations, there are a few considerations to keep in mind. Special populations include individuals with specific health conditions or demographics that may require special attention during treatment. Here are some examples:

  1. Renal Impairment: Sovaldi can be used in individuals with mild to moderate renal impairment without requiring dosage adjustments. However, for individuals with severe renal impairment or end-stage renal disease, Sovaldi should be used with caution, as limited data is available in this population. Close monitoring of renal function and potential dosage adjustments may be necessary.
  2. Hepatic Impairment: It is generally safe for use in individuals with mild to moderate hepatic impairment (liver dysfunction). However, for individuals with severe hepatic impairment, the use of Sovaldi may require careful consideration and monitoring due to limited data available in this population.
  3. Pediatric Population: This drug, in combination with other antiviral medications, is approved for the treatment of chronic hepatitis C in pediatric patients aged 3 years and older. The dosage and duration of treatment may vary depending on the child’s age, weight, and specific hepatitis C genotype. Pediatric patients should be monitored closely during treatment.
  4. Geriatric Population: There are no specific dosage adjustments required for geriatric (elderly) patients when using Sovaldi. However, as individuals age, they may have an increased risk of comorbidities and potential drug interactions. Close monitoring and individualized treatment plans are essential for geriatric patients.
  5. Pregnancy and Breastfeeding: Sovaldi is not recommended for use during pregnancy due to limited safety data. Women of childbearing potential should use effective contraception during treatment and discuss family planning with their healthcare professional. The safety of Sovaldi during breastfeeding is also not established, and the potential risks and benefits should be evaluated before starting treatment.

Possible Side Effects

Common side effects

While Sovaldi (Sofosbuvir) is generally well-tolerated, it may cause certain side effects in some individuals. Here is a list of commonly reported side effects associated with Sovaldi:

  1. Headache: Some individuals may experience mild to moderate headaches while taking this medicine.
  2. Fatigue: Fatigue or a feeling of tiredness can occur during treatment with Sovaldi.
  3. Nausea: Nausea, sometimes accompanied by a loss of appetite, is a potential side effect of Sovaldi.
  4. Insomnia: Difficulty sleeping or insomnia may occur in some individuals using this option.
  5. Diarrhea: Sovaldi can cause loose stools or diarrhea in certain individuals.
  6. Skin Rash: A skin rash, which may be mild or moderate, can occur as a side effect.
  7. Muscle or Joint Pain: Some individuals may experience muscle or joint pain.
  8. Dizziness: Dizziness or lightheadedness can occur in rare cases during the treatment.
  9. Abdominal Pain: Abdominal discomfort or pain may be reported as a side effect of Sovaldi.
  10. Difficulty Concentrating: Some individuals may experience difficulties with concentration or mental focus while on Sovaldi.

Serious adverse reactions

While rare, Sovaldi (Sofosbuvir) may cause some uncommon side effects in a small number of individuals. Here is a list of rare side effects that have been reported with Sovaldi:

  1. Allergic Reactions: In rare cases, it may cause severe allergic reactions, including swelling of the face, lips, tongue, or throat, hives, itching, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur.
  2. Serious Skin Reactions: Rarely, it can lead to serious skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis. These conditions are characterized by severe blistering, peeling, and redness of the skin and require immediate medical attention.
  3. Liver Problems: Sovaldi is used to treat hepatitis C, which primarily affects the liver. However, in rare instances, Sovaldi may cause worsening of liver function or other liver-related complications. Symptoms may include jaundice (yellowing of the skin or eyes), dark urine, pale stools, abdominal pain, or swelling. If any signs of liver problems occur, prompt medical evaluation is necessary.
  4. Cardiovascular Events: Although rare, there have been reports of cardiovascular events such as heart attack or irregular heart rhythms (arrhythmias) in individuals receiving Sovaldi, particularly when used in combination with other medications. Individuals with pre-existing cardiovascular conditions may be at a higher risk.
  5. Mood Changes: Rarely, Sovaldi may cause mood changes, including depression, anxiety, or suicidal thoughts. It is important to promptly report any significant changes in mood or mental health to a healthcare professional.

Sovaldi Price

Sovaldi is known to be a high-cost medication, particularly the branded version manufactured by Gilead Sciences. When Sovaldi was initially introduced in 2013, its list price for a 12-week treatment course was around $84,000 in the United States. The high cost of Sovaldi and other direct-acting antivirals led to significant debates and discussions regarding their affordability and accessibility.

It’s worth noting that prices can vary widely across different countries and regions due to various factors, including negotiation between pharmaceutical companies and healthcare systems or insurance providers. Additionally, the availability of generic versions of Sovaldi has helped to lower the cost of treatment, making it more accessible in some regions.

To obtain accurate and up-to-date pricing information for Sovaldi or its generic versions, it is recommended to consult local pharmacies, healthcare providers, or insurance companies. They can provide specific pricing details based on your location and individual circumstances.

Storage and Disposal

Storage instructions

The storage instructions for Sovaldi (Sofosbuvir) typically include the following guidelines:

  1. Temperature: Store Sovaldi at room temperature, preferably between 20°C to 25°C (68°F to 77°F).
  2. Protect from Light: Keep Sovaldi away from direct sunlight or sources of excessive light exposure. Store it in its original container or packaging to provide protection from light.
  3. Moisture: Protect Sovaldi from moisture by keeping it in a dry environment. Avoid storing it in areas prone to high humidity, such as the bathroom.
  4. Childproofing: Keep Sovaldi out of the reach of children and pets. Ensure proper childproofing measures, such as storing it in a secure location or using child-resistant caps if provided.
  5. Original Packaging: It is recommended to store Sovaldi in its original packaging until it is ready for use. This helps in maintaining proper identification and labeling of the medication.
  6. Do Not Freeze: Do not freeze Sovaldi, as freezing temperatures can affect its stability and efficacy.

Disposal of unused medication

When it comes to the disposal of unused Sovaldi (Sofosbuvir) or any medication, it is important to follow proper guidelines to ensure safe and environmentally friendly disposal. Here are some recommendations:

  1. Consultation: Seek guidance from your healthcare professional or pharmacist regarding the proper disposal of unused Sovaldi. They can provide specific instructions based on local regulations and guidelines.
  2. Medication Take-Back Programs: Check if there are any authorized medication take-back programs or events in your area. These programs allow individuals to safely dispose of unused medications, including Sovaldi, at designated collection sites. This helps prevent improper disposal and minimizes environmental impact.
  3. Disposal with Household Waste: If a medication take-back program is not available or accessible, carefully follow these steps to dispose of unused Sovaldi with your household waste:
    • Remove Sovaldi from its original packaging and mix it with an undesirable substance such as dirt, coffee grounds, or cat litter. This helps make the medication less appealing and less likely to be accidentally consumed.
    • Place the mixture in a sealable bag, container, or empty can to prevent leakage.
    • Conceal or cover any personal information on the original packaging before discarding it.
    • Dispose of the sealed bag or container with your regular household waste.
  4. Do Not Flush or Pour Down the Drain: Avoid flushing Sovaldi or pouring it down the drain, as this can potentially contaminate water sources and harm the environment.

Disclaimer: The information provided on this website is for informational purposes only and is not intended as medical advice. The product is a prescription medication and should only be taken under the supervision of a qualified healthcare provider. This information is not intended to diagnose, treat, cure, or prevent any disease and should not be used as a substitute for professional medical advice. Always consult with a qualified healthcare provider before starting or stopping any medication or if you have any questions or concerns about your health.